Testing is usually performed on the fifth day after egg retrieval or the blastocyst stage. At this point there are many cells in the developing embryo. Our embryologist, using a laser and microscopic techniques, delicately creates a hole in the shell of the embryo and then removes several cells from each of the developing embryos. These are then placed in a special solution and delivered to our affiliate laboratory, CooperGenomics(one of the most experienced cytogenetics laboratories in the world) and now using artificial intelligence technology. The laboratory will then determine which embryos are affected. We feel strongly that the most accurate test should be performed on these cells. Not all IVF programs use the most accurate testing techniques.
That information is relayed back to us and the good embryos are then used for embryo transfer. Over 300 different disorders can currently be diagnosed and prevented using PGT-M.
Recurrent miscarriages and repetitive failed IVF may also be due to genetic abnormalities. Sometimes PGT-A can help identify these abnormalities. If a parent or parents have or are carriers of a certain genetic disorder, the embryos created can be tested for this disease. Special probes are designed specifically for the parent’s disorder.
PGT-M is frequently performed with PGT-A. Once the cells are isolated, the specific probe can be used to identify affected embryos. Only embryos classified as normal will be transferred back into the woman’s uterus.
PGT-SR is different from PGT-A, as in these cases the chromosome abnormalities are hereditary due to one or both parents having a balanced chromosome “structural rearrangement.” PGT-SR reduces the risk of having a pregnancy or child with an unbalanced structural abnormality, which involves extra or missing genetic material and typically results in a pregnancy loss.
PGT combined with our cutting edge research involving the embryoscope and time-lapse photography may help select better quality embryos for transfer, decreasing the time to pregnancy and delivery.